1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)* to 1-linoleoyl-gpe (18:2)*

Numerator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Denominator Metabolite

Structure of 1-linoleoyl-gpe (18:2)*
Metabolite Accession: GCST90199793
Name: 1-linoleoyl-gpe (18:2)*
Hmdb Id: HMDB0011507
Super Pathway: NA
Sub Pathway: NA
Inchikey: DBHKHNGBVGWQJE

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.625
Position:
61570783
SE (Ratio):
0.021
Effect Allele:
C
Z-score (Ratio):
-29.832
Reference Allele:
T
-log10(P):
-448.602
MAF:
0.338
Beta (Num):
-0.342
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.283
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.9[1], 10[2], 11[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.12[1], 13[2]

Ratio Explanation:

The ratio reflects the balance between a phosphatidylcholine containing arachidonic acid and a phosphatidylethanolamine containing linoleic acid, influenced by FADS desaturase activity.1[1], 2[2], 14[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, influenced by genetic factors, likely shifts the balance of polyunsaturated fatty acids, impacting glycerophospholipid composition. This dysregulation is associated with hypercholesterolemia and cholelithiasis, potentially through effects on lipid metabolism and inflammation.6[1], 15[2], 16[3], 17[4], 18[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data