1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)* to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174528

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.609
Position:
61543499
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-37.877
Reference Allele:
T
-log10(P):
-721.196
MAF:
0.369
Beta (Num):
-0.303
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.305
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
MYRF TMEM258 FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, omega-6 fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, omega-6 fatty acid metabolism.4[1], 6[2]

Ratio Explanation:

The ratio of phosphatidylcholines containing arachidonic acid (20:4) to those with dihomo-linolenic acid (20:3) is a direct measure of FADS1 enzymatic activity.7[1], 8[2]

Ratio Evidence:

canonical reaction catalyzed by the enzyme

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 alter its desaturase efficiency, directly impacting the ratio of arachidonic acid (20:4) to its precursor (20:3).9[1], 10[2] This metabolic shift is causally linked to pure hypercholesterolemia and other disorders of lipoprotein metabolism, as confirmed by Mendelian randomization and association studies.11[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data