1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)* to 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*

Numerator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Denominator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.738
Position:
61570783
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-33.378
Reference Allele:
T
-log10(P):
-560.769
MAF:
0.338
Beta (Num):
-0.342
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.396
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Linoleic acid metabolism4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lipid transport5[1]

Ratio Explanation:

The ratio reflects FADS1/FADS2 desaturase activity, comparing a phosphatidylcholine containing the product arachidonic acid (20:4) to a phosphatidylethanolamine with the precursor linoleic acid (18:2).6[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, impacting the balance of pro-inflammatory arachidonic acid and its precursors.1[1], 6[2] This altered lipid profile is associated with hypercholesterolemia and an inflammatory state, potentially increasing the risk for benign colorectal neoplasms and other inflammatory conditions.6[3], 7[4], 8[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data