1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)* to 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*

Numerator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Denominator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.578
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-27.582
Reference Allele:
C
-log10(P):
-383.934
MAF:
0.338
Beta (Num):
-0.341
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.237
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.2[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, linoleic and alpha-linolenic acid metabolism.2[1]

Ratio Explanation:

The ratio reflects the activity of FADS1/FADS2, which convert linoleic/linolenic acids (denominator) to long-chain polyunsaturated fatty acids like arachidonic acid (numerator).

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase activity, affecting the balance of pro- and anti-inflammatory fatty acids, which is associated with cholelithiasis, hypercholesterolemia, and benign colon neoplasms.3[1], 4[2], 5[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data