1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)* to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Metabolite Accession: GCST90200078
Name: 1-myristoyl-2-arachidonoyl-gpc (14:0/20:4)*
Hmdb Id: HMDB0007883
Super Pathway: NA
Sub Pathway: NA
Inchikey: SRQSAJRUMDQMMS

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.502
Position:
61581764
SE (Ratio):
0.022
Effect Allele:
C
Z-score (Ratio):
-23.275
Reference Allele:
T
-log10(P):
-274.239
MAF:
0.307
Beta (Num):
-0.347
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.155
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism, carnitine synthesis.7[1], 8[2], 9[3], 10[4]

Ratio Explanation:

The ratio reflects FADS1 activity, where higher levels suggest increased production of arachidonic acid-containing phospholipids relative to the transport of dihomo-linolenic acid precursor.11[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity is linked to altered lipid profiles and inflammation, potentially contributing to asthma and lipoprotein metabolism disorders.12[1], 13[2], 14[3] This may influence adipocyte and immune cell function, connecting to phenotypes like hernias and dermatitis.

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data