1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)* to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Metabolite Accession: GCST90200079
Name: 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Hmdb Id: HMDB0009069
Super Pathway: NA
Sub Pathway: NA
Inchikey: PECSWFQRRFRZPW

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.248
Position:
61593816
SE (Ratio):
0.023
Effect Allele:
T
Z-score (Ratio):
-10.610
Reference Allele:
C
-log10(P):
-58.880
MAF:
0.338
Beta (Num):
-0.122
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.125
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, PUFA biosynthesis6[1], 7[2]

Ratio Explanation:

This ratio reflects FADS-mediated conversion of linoleic acid (18:2) precursors into arachidonic acid (20:4) products, indicating desaturase pathway efficiency.1[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid (PUFA) metabolism, reflected by this ratio. This dysregulation of PUFA balance, critical for inflammation and lipid modulation, likely drives the associated risk for pure hypercholesterolaemia and other inflammatory or lipid-related disorders like cholelithiasis.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data