1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)* to 1-oleoyl-gpe (18:1)

Numerator Metabolite

Structure of 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Metabolite Accession: GCST90200079
Name: 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Hmdb Id: HMDB0009069
Super Pathway: NA
Sub Pathway: NA
Inchikey: PECSWFQRRFRZPW

Denominator Metabolite

Structure of 1-oleoyl-gpe (18:1)
Metabolite Accession: GCST90199794
Name: 1-oleoyl-gpe (18:1)
Hmdb Id: HMDB0011506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PYVRVRFVLRNJLY

Associated Genomic Regions

Region: rs174567

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.198
Position:
61593005
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
-10.277
Reference Allele:
A
-log10(P):
-55.370
MAF:
0.346
Beta (Num):
-0.122
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism; Phospholipid remodeling.2[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism; Phospholipid remodeling.2[1]

Ratio Explanation:

The ratio reflects the acylation of 1-oleoyl-gpe (denominator) with arachidonic acid to form 1-oleoyl-2-arachidonoyl-gpe (numerator), a key step in phospholipid remodeling.2[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters arachidonic acid synthesis, impacting this ratio.1[1] This change in fatty acid metabolism influences lipid profiles and inflammatory pathways, plausibly increasing risk for cholelithiasis, dyslipidemia, and type 2 diabetes.4[2], 5[3], 6[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data