1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)* to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Metabolite Accession: GCST90200079
Name: 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Hmdb Id: HMDB0009069
Super Pathway: NA
Sub Pathway: NA
Inchikey: PECSWFQRRFRZPW

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.449
Position:
61592362
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
-22.046
Reference Allele:
A
-log10(P):
-246.335
MAF:
0.345
Beta (Num):
-0.123
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.326
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid Metabolism, Glycerophosphoethanolamine metabolism.4[1]

Denominator Metabolite Explanation:

Phosphatidylcholine Metabolism.5[1]

Ratio Explanation:

The ratio reflects the relative activity of FADS1/FADS2, converting shorter-chain fatty acids to long-chain polyunsaturated fatty acids like arachidonic acid, impacting inflammation and cell membranes.2[1], 6[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, reflected in the metabolite ratio, influences the production of inflammatory mediators derived from arachidonic acid, potentially contributing to the pathogenesis of inflammatory conditions like cholelithiasis and type 2 diabetes, which are associated with dysregulated lipid metabolism.1[1], 7[2], 8[3]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data