1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)* to 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*

Numerator Metabolite

Structure of 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Metabolite Accession: GCST90200079
Name: 1-oleoyl-2-arachidonoyl-gpe (18:1/20:4)*
Hmdb Id: HMDB0009069
Super Pathway: NA
Sub Pathway: NA
Inchikey: PECSWFQRRFRZPW

Denominator Metabolite

Structure of 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Metabolite Accession: GCST90200063
Name: 1-palmitoyl-2-docosahexaenoyl-gpe (16:0/22:6)*
Hmdb Id: HMDB0008946
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPWUZHVZZKSTPV

Associated Genomic Regions

Region: rs174560

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.156
Position:
61581764
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-9.389
Reference Allele:
T
-log10(P):
-46.555
MAF:
0.308
Beta (Num):
-0.126
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.030
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs3734398

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
6
Beta (Ratio):
0.159
Position:
10982973
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
10.275
Reference Allele:
T
-log10(P):
-55.357
MAF:
0.427
Beta (Num):
0.084
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.075
SE (Den):
0.015
No CNV overlap
rQTL cluster:
112
Reaction Distance:
NA
Closest Genes:
ELOVL2 SYCP2L RP11-637O19.3 GCM2 SMIM13

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.2[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.3[1]

Ratio Explanation:

The ratio reflects the balance of two phosphatidylethanolamines; FADS1 influences the abundance of arachidonic acid (20:4), a component of the numerator.1[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by eQTL colocalization, alters the balance of long-chain polyunsaturated fatty acids. This dysregulation of lipid metabolism is associated with an increased risk for cholelithiasis and other disorders of lipoprotein metabolism.5[1], 6[2], 7[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data