1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Metabolite Accession: GCST90199649
Name: 1-stearoyl-2-arachidonoyl-gpi (18:0/20:4)
Hmdb Id: HMDB0009815
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRTOMQDUKGRFDJ

Associated Genomic Regions

Region: rs174564

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Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.352
Position:
61588305
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
19.261
Reference Allele:
A
-log10(P):
-188.675
MAF:
0.344
Beta (Num):
0.106
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.246
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
19
Beta (Ratio):
0.353
Position:
54677189
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
19.695
Reference Allele:
C
-log10(P):
-197.151
MAF:
0.435
Beta (Num):
0.179
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.174
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis and fatty acid remodeling.10[1], 11[2], 12[3], 13[4]

Denominator Metabolite Explanation:

GPI anchor biosynthesis and fatty acid remodeling.10[1], 11[2], 12[3], 13[4]

Ratio Explanation:

The ratio reflects the balance of acyl chains in GPI anchors, likely influenced by the activity of MBOAT7 incorporating arachidonic acid (20:4) and FADS enzymes.6[1], 14[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced MBOAT7 or FADS1 activity can alter the balance of pro-inflammatory (arachidonic acid-derived) and other lipids, contributing to inflammatory conditions like IBD and metabolic phenotypes like dyslipidemia.15[1], 9[2], 16[3], 17[4], 18[5], 19[6]

Phenotype Driver:

Gene-centric:MBOAT7

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data