1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.189
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
8.703
Reference Allele:
C
-log10(P):
-40.277
MAF:
0.339
Beta (Num):
0.104
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.085
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophosphoinositol metabolism, GPI anchor biosynthesis.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the activity of FADS enzymes, which regulate the balance between glycerophospholipid synthesis and the production of long-chain polyunsaturated fatty acids like DHA.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, impacting the balance of pro-inflammatory and anti-inflammatory lipids derived from omega-3 and omega-6 pathways.11[1], 12[2], 2[3] This imbalance is linked to various inflammatory (asthma, IBD) and metabolic (T2D, hypercholesterolemia) phenotypes.11[4], 12[5], 13[6], 14[7], 15[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data