1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)
Metabolite Accession: GCST90199653
Name: 1-myristoyl-2-palmitoyl-gpc (14:0/16:0)
Hmdb Id: HMDB0007869
Super Pathway: NA
Sub Pathway: NA
Inchikey: RFVFQQWKPSOBED

Associated Genomic Regions

Region: rs8736

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
19
Beta (Ratio):
0.191
Position:
54677189
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
13.574
Reference Allele:
C
-log10(P):
-94.969
MAF:
0.435
Beta (Num):
0.179
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.012
SE (Den):
0.016
No CNV overlap
rQTL cluster:
6
Reaction Distance:
NA
Closest Genes:
MBOAT7 TMC4 LENG1 TSEN34 CNOT3

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

Ratio of a GPI-anchored lipid to a phosphatidylcholine, potentially reflecting membrane composition or remodeling activity influenced by the causal gene TMC4.3[1], 7[2], 1[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered TMC4 function likely changes this lipid ratio, affecting membrane-related processes, which may contribute to cardiometabolic phenotypes like cholelithiasis and lipoprotein disorders by impacting cellular lipid handling and signaling.1[1], 9[2]

Phenotype Driver:

Gene-centric:TMC4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data