1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to palmitoylcarnitine (c16)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of palmitoylcarnitine (c16)
Metabolite Accession: GCST90199666
Name: palmitoylcarnitine (c16)
Hmdb Id: HMDB0000222
Super Pathway: NA
Sub Pathway: NA
Inchikey: XOMRRQXKHMYMOC

Associated Genomic Regions

Region: rs174554

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.180
Position:
61579463
SE (Ratio):
0.019
Effect Allele:
G
Z-score (Ratio):
9.442
Reference Allele:
A
-log10(P):
-47.054
MAF:
0.338
Beta (Num):
0.103
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.077
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid metabolism, GPI-anchor biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio reflects the balance between incorporating fatty acids into GPI anchors and transporting them for mitochondrial oxidation, a balance influenced by FADS activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid levels, which are precursors for inflammatory mediators.1[1], 9[2], 10[3] This altered inflammatory and lipid state is linked to phenotypes like cholelithiasis, hypercholesterolemia, and inflammatory bowel disease.9[4], 11[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data