1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to stearidonate (18:4n3)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of stearidonate (18:4n3)
Metabolite Accession: GCST90199721
Name: stearidonate (18:4n3)
Hmdb Id: HMDB0006547
Super Pathway: NA
Sub Pathway: NA
Inchikey: JIWBIWFOSCKQMA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.226
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
10.665
Reference Allele:
A
-log10(P):
-59.472
MAF:
0.344
Beta (Num):
0.106
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.120
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism

Ratio Explanation:

This ratio likely reflects FADS2 activity, which synthesizes stearidonate.3[1], 6[2], 7[3], 8[4], 9[5], 10[6] Reduced FADS2 function would decrease the denominator relative to GPI lipids incorporating other fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid (PUFA) levels, reflected in the ratio.5[1], 6[2] Since PUFAs modulate inflammation and lipid levels, this genetically driven variation likely contributes to phenotypes like cholelithiasis, hypercholesterolemia, and inflammatory conditions such as asthma and IBD.6[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data