1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to 1-stearoyl-gpc (18:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of 1-stearoyl-gpc (18:0)
Metabolite Accession: GCST90199732
Name: 1-stearoyl-gpc (18:0)
Hmdb Id: HMDB0010384
Super Pathway: NA
Sub Pathway: NA
Inchikey: IHNKQIMGVNPMTC

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.211
Position:
61581764
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
10.295
Reference Allele:
T
-log10(P):
-55.564
MAF:
0.308
Beta (Num):
0.096
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
-0.115
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis

Denominator Metabolite Explanation:

Phosphatidylcholine metabolism, Lysophospholipid metabolism

Ratio Explanation:

This ratio may reflect FADS1 activity, which influences the fatty acid pool (saturated vs. unsaturated) used for synthesizing complex lipids like GPI anchors and lysophosphatidylcholines.4[1]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1 activity impacts the balance of fatty acids, affecting inflammatory precursors and lipid composition.3[1], 5[2], 6[3], 7[4] This dysregulation is linked to inflammatory conditions like asthma and disorders of lipoprotein metabolism, which are observed as associated phenotypes.5[5], 6[6], 7[7], 8[8]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data