1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to 1-palmitoyl-gpc (16:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of 1-palmitoyl-gpc (16:0)
Metabolite Accession: GCST90199733
Name: 1-palmitoyl-gpc (16:0)
Hmdb Id: HMDB0010382
Super Pathway: NA
Sub Pathway: NA
Inchikey: ASWBNKHCZGQVJV

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.175
Position:
61581764
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
9.429
Reference Allele:
T
-log10(P):
-46.930
MAF:
0.308
Beta (Num):
0.096
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.079
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis, Phospholipid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysolipid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio reflects FADS1/2 activity, where higher levels indicate greater desaturation of fatty acids (producing oleoyl-18:1) and their incorporation into GPI-anchored proteins.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter enzyme activity, impacting polyunsaturated fatty acid levels.10[1], 11[2] This dysregulates inflammatory pathways and lipid profiles, contributing to phenotypes like asthma, hypercholesterolemia, and cholelithiasis, a known cholesterol-related disorder.12[3], 13[4], 14[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data