1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.188
Position:
61581764
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
10.241
Reference Allele:
T
-log10(P):
-55.000
MAF:
0.308
Beta (Num):
0.096
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
-0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Lysophospholipid metabolism.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect the balance between GPI anchor synthesis, requiring specific fatty acids, and the breakdown or remodeling of phosphatidylethanolamines, influenced by FADS1 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The FADS1 gene influences the composition of fatty acids, which are essential components of both the numerator and denominator metabolites.11[1], 12[2] Altered FADS1 activity can impact the balance of these lipids, which is associated with dyslipidemia, cholelithiasis and valvular heart disease.1[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data