1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to docosapentaenoate (n6 dpa; 22:5n6)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Associated Genomic Regions

Region: rs174553

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.217
Position:
61575158
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
9.942
Reference Allele:
A
-log10(P):
-51.953
MAF:
0.339
Beta (Num):
0.105
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.112
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis7[1], 8[2]

Ratio Explanation:

This ratio reflects FADS-mediated polyunsaturated fatty acid (PUFA) synthesis, comparing a GPI-anchor species with a downstream omega-6 PUFA, likely indicating FADS activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, impacting polyunsaturated fatty acid levels.4[1], 6[2] This dysregulation is linked to phenotypes like hypercholesterolemia, cholelithiasis, and asthma, likely through effects on inflammation and lipid metabolism.4[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data