1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Metabolite Accession: GCST90200045
Name: 1-stearoyl-2-arachidonoyl-gpe (18:0/20:4)
Hmdb Id: HMDB0009003
Super Pathway: NA
Sub Pathway: NA
Inchikey: ANRKEHNWXKCXDB

Associated Genomic Regions

Region: rs174566

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.329
Position:
61592362
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
16.165
Reference Allele:
A
-log10(P):
-133.661
MAF:
0.345
Beta (Num):
0.104
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.224
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism.5[1]

Ratio Explanation:

This ratio reflects FADS1/FADS2 activity; lower levels indicate higher desaturation, converting precursors into arachidonic acid (20:4), a key component of the denominator metabolite.6[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters polyunsaturated fatty acid metabolism, specifically arachidonic acid (20:4) synthesis. This dysregulation impacts the balance of inflammatory mediators, contributing to the associated inflammatory (asthma), metabolic (T2D, cholelithiasis, hypercholesterolemia), and cardiovascular phenotypes.7[1], 8[2]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data