1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Metabolite Accession: GCST90200048
Name: 1-(1-enyl-palmitoyl)-2-arachidonoyl-gpe (p-16:0/20:4)*
Hmdb Id: HMDB0011352
Super Pathway: NA
Sub Pathway: NA
Inchikey: UUYSKERSKRMYME

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.190
Position:
61588305
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
8.692
Reference Allele:
A
-log10(P):
-40.175
MAF:
0.344
Beta (Num):
0.106
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.084
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid Metabolism

Denominator Metabolite Explanation:

Plasmalogen Synthesis

Ratio Explanation:

The ratio reflects fatty acid desaturase (FADS) activity, contrasting a phosphatidylinositol with a plasmalogen containing arachidonic acid, a direct product of FADS1/2 enzymes.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants influence polyunsaturated fatty acid levels, impacting lipid metabolism and inflammation.4[1], 5[2] This contributes to associated phenotypes like cholelithiasis, hypercholesterolemia, and inflammatory conditions such as asthma by altering the balance of pro- and anti-inflammatory lipid mediators.6[3], 7[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data