1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to myristoyl dihydrosphingomyelin (d18:0/14:0)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of myristoyl dihydrosphingomyelin (d18:0/14:0)*
Metabolite Accession: GCST90200049
Name: myristoyl dihydrosphingomyelin (d18:0/14:0)*
Hmdb Id: HMDB0012085
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJAFYELZQYPMQG

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.157
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
8.645
Reference Allele:
T
-log10(P):
-39.760
MAF:
0.346
Beta (Num):
0.102
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.055
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, fatty acid biosynthesis.7[1], 8[2], 9[3], 10[4]

Denominator Metabolite Explanation:

Sphingolipid metabolism.11[1], 12[2], 13[3], 14[4]

Ratio Explanation:

This ratio reflects the balance between glycerophospholipid synthesis, influenced by FADS desaturase activity on fatty acid precursors, and sphingolipid pathway activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 variants alter fatty acid desaturation, affecting complex lipid composition.15[1], 16[2], 17[3], 18[4] This dysregulated lipid metabolism is a known risk factor for the associated phenotypes of hypercholesterolemia, cholelithiasis, and Type 2 diabetes by affecting inflammatory pathways and lipid profiles.2[5], 16[6], 19[7], 20[8]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data