1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to nisinate (24:6n3)

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of nisinate (24:6n3)
Metabolite Accession: GCST90200122
Name: nisinate (24:6n3)
Hmdb Id: HMDB0013025
Super Pathway: NA
Sub Pathway: NA
Inchikey: YHGJECVSSKXFCJ

Associated Genomic Regions

Region: rs174568

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.260
Position:
61593816
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
10.430
Reference Allele:
C
-log10(P):
-56.970
MAF:
0.338
Beta (Num):
0.103
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.156
SE (Den):
0.022
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis

Denominator Metabolite Explanation:

Omega-3 fatty acid metabolism

Ratio Explanation:

The ratio reflects the balance between glycerophosphoinositol synthesis and polyunsaturated fatty acid metabolism, potentially indicating altered cell membrane composition and signaling processes influenced by FADS activity.1[1], 4[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Altered FADS1/FADS2 activity, indicated by the metabolite ratio, impacts polyunsaturated fatty acid levels, which is linked to dyslipidemia and an increased risk of cholelithiasis (gallstones) and type 2 diabetes due to effects on cholesterol metabolism and inflammation.11[1], 12[2], 13[3], 14[4], 15[5], 16[6], 17[7], 18[8], 19[9], 20[10], 21[11]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data