1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to sphingomyelin (d17:2/16:0, d18:2/15:0)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Metabolite Accession: GCST90200125
Name: sphingomyelin (d17:2/16:0, d18:2/15:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.180
Position:
61557803
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
9.589
Reference Allele:
T
-log10(P):
-48.468
MAF:
0.346
Beta (Num):
0.102
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.079
SE (Den):
0.014
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylinositol synthesis, Fatty acid metabolism

Denominator Metabolite Explanation:

Sphingolipid metabolism, Fatty acid metabolism

Ratio Explanation:

The ratio reflects the balance between phosphatidylinositol and sphingomyelin synthesis, influenced by FADS1's role in providing polyunsaturated fatty acid precursors for various lipid species.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered FADS1 activity impacts the availability of specific PUFAs, influencing the composition of signaling lipids and cell membranes. This dysregulation is linked to inflammatory conditions and altered cholesterol metabolism, contributing to phenotypes like inflammatory bowel disease and cholelithiasis.5[1], 6[2], 7[3], 8[4], 9[5], 10[6], 11[7]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data