1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to sphingomyelin (d18:2/21:0, d16:2/23:0)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Metabolite Accession: GCST90200129
Name: sphingomyelin (d18:2/21:0, d16:2/23:0)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.190
Position:
61588305
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
9.529
Reference Allele:
A
-log10(P):
-47.892
MAF:
0.344
Beta (Num):
0.106
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.084
SE (Den):
0.013
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

GPI anchor biosynthesis.3[1]

Denominator Metabolite Explanation:

Sphingolipid biosynthesis.4[1], 5[2]

Ratio Explanation:

This ratio reflects a balance in membrane lipid composition.6[1] FADS1 activity influences fatty acid pools, impacting the synthesis of both GPI-anchors and sphingomyelins.7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

FADS1 variation alters PUFA levels, impacting both membrane structure and the synthesis of inflammatory molecules.8[1], 9[2], 10[3] This dual effect on lipid metabolism and inflammation likely drives the associated phenotypes like IBD, asthma, cholelithiasis and cardiovascular disease.7[4], 8[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data