1-palmitoyl-2-oleoyl-gpi (16:0/18:1)* to cerotoylcarnitine (c26)*

Numerator Metabolite

Structure of 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Metabolite Accession: GCST90200080
Name: 1-palmitoyl-2-oleoyl-gpi (16:0/18:1)*
Hmdb Id: HMDB0009783
Super Pathway: NA
Sub Pathway: NA
Inchikey: PDLAMJKMOKWLAJ

Denominator Metabolite

Structure of cerotoylcarnitine (c26)*
Metabolite Accession: GCST90200136
Name: cerotoylcarnitine (c26)*
Hmdb Id: HMDB0006347
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOCKWDDTAHPJSX

Associated Genomic Regions

Region: rs174553

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.178
Position:
61575158
SE (Ratio):
0.020
Effect Allele:
G
Z-score (Ratio):
8.843
Reference Allele:
A
-log10(P):
-41.521
MAF:
0.339
Beta (Num):
0.105
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.073
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycosylphosphatidylinositol (GPI) anchor biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio reflects fatty acid desaturase (FADS1/FADS2) activity, increasing unsaturated GPI species (numerator) relative to very-long-chain saturated fatty acid metabolism (denominator).8[1]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene activity, reflected by the ratio, influences the balance of fatty acids.9[1], 10[2] This dysregulation of lipid metabolism and inflammatory precursors plausibly contributes to phenotypes like cholelithiasis, inflammatory bowel disease, and disorders of lipoprotein metabolism.11[3], 12[4], 13[5], 14[6]

Phenotype Driver:

Gene-centric:FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data