1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)* to 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*

Numerator Metabolite

Structure of 1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)*
Metabolite Accession: GCST90200081
Name: 1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)*
Hmdb Id: HMDB0008123
Super Pathway: NA
Sub Pathway: NA
Inchikey: FPEVDFOXMCHLKL

Denominator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Metabolite Accession: GCST90200057
Name: 1-(1-enyl-palmitoyl)-2-oleoyl-gpc (p-16:0/18:1)*
Hmdb Id: HMDB0007996
Super Pathway: NA
Sub Pathway: NA
Inchikey: MPQGNHKVOVYEEN

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.211
Position:
116648917
SE (Ratio):
0.027
Effect Allele:
G
Z-score (Ratio):
7.895
Reference Allele:
C
-log10(P):
-33.473
MAF:
0.131
Beta (Num):
0.120
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
-0.092
SE (Den):
0.022
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylcholine biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Plasmalogen biosynthesis6[1], 7[2]

Ratio Explanation:

This ratio compares a phosphatidylcholine to a plasmalogen. Its alteration, linked to APOA5, likely reflects changes in lipoprotein composition and triglyceride metabolism.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the APOA5 gene cluster alter apolipoprotein function, leading to dyslipidemia, including changes in triglyceride levels and lipoprotein composition, which are major risk factors for the associated cardiovascular phenotypes like myocardial infarction and coronary atherosclerosis.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data