1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)* to sphingomyelin (d18:2/24:2)*

Numerator Metabolite

Structure of 1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)*
Metabolite Accession: GCST90200081
Name: 1-oleoyl-2-docosahexaenoyl-gpc (18:1/22:6)*
Hmdb Id: HMDB0008123
Super Pathway: NA
Sub Pathway: NA
Inchikey: FPEVDFOXMCHLKL

Denominator Metabolite

Structure of sphingomyelin (d18:2/24:2)*
Metabolite Accession: GCST90200124
Name: sphingomyelin (d18:2/24:2)*
Hmdb Id: HMDB0240644
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAWJSGKLPKMOGG

Associated Genomic Regions

Region: rs964184

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.233
Position:
116648917
SE (Ratio):
0.028
Effect Allele:
G
Z-score (Ratio):
8.268
Reference Allele:
C
-log10(P):
-36.535
MAF:
0.131
Beta (Num):
0.120
Novel Locus:
Yes ✔️
SE (Num):
0.022
Beta (Den):
-0.113
SE (Den):
0.021
No CNV overlap
rQTL cluster:
248
Reaction Distance:
NA
Closest Genes:
ZNF259 BUD13 APOA5 APOA4 APOC3

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, phosphatidylcholine biosynthesis.4[1]

Denominator Metabolite Explanation:

Sphingolipid metabolism.5[1], 6[2], 7[3]

Ratio Explanation:

This ratio may reflect lipoprotein particle composition, which is regulated by the APOA1/C3/A4/A5 gene cluster and is associated with cardiovascular disease risk.1[1], 8[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the APOA1/C3/A4/A5 cluster influence triglyceride and lipoprotein metabolism.1[1], 3[2], 10[3] This dysregulation, reflected in the PC/SM ratio, contributes to hypercholesterolemia and an increased risk of myocardial infarction and other atherosclerotic diseases.8[4], 9[5], 11[6], 12[7]

Phenotype Driver:

Gene-centric:APOA5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data