1-oleoyl-2-linoleoyl-gpe (18:1/18:2)* to 1-arachidonylglycerol (20:4)

Numerator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonylglycerol (20:4)
Metabolite Accession: GCST90199770
Name: 1-arachidonylglycerol (20:4)
Hmdb Id: HMDB0011578
Super Pathway: NA
Sub Pathway: NA
Inchikey: DCPCOKIYJYGMDN

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.665
Position:
61588305
SE (Ratio):
0.024
Effect Allele:
G
Z-score (Ratio):
28.190
Reference Allele:
A
-log10(P):
-400.891
MAF:
0.345
Beta (Num):
0.395
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.271
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Monoacylglycerol synthesis, Endocannabinoid signaling.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio reflects the balance between a phospholipid containing oleic/linoleic acid and a signaling lipid derived from arachidonic acid, a product of FADS2/FADS1 activity.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS gene variants alter desaturase activity, affecting the balance of pro-inflammatory and anti-inflammatory fatty acids, which is linked to metabolic disorders like Type 2 diabetes, hypercholesterolemia, and cholelithiasis.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data