1-oleoyl-2-linoleoyl-gpe (18:1/18:2)* to 1-stearoyl-gpe (18:0)

Numerator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-gpe (18:0)
Metabolite Accession: GCST90199772
Name: 1-stearoyl-gpe (18:0)
Hmdb Id: HMDB0011130
Super Pathway: NA
Sub Pathway: NA
Inchikey: BBYWOYAFBUOUFP

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.468
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
26.424
Reference Allele:
T
-log10(P):
-352.621
MAF:
0.348
Beta (Num):
0.390
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.078
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerophospholipid metabolism

Ratio Explanation:

This ratio may reflect the activity of FADS1/FADS2, which desaturate fatty acids, influencing the balance between more and less saturated glycerophosphoethanolamines.1[1], 2[2], 3[3], 4[4], 5[5], 6[6]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the balance of polyunsaturated fatty acids, which is associated with changes in cholesterol levels.7[1], 8[2], 9[3] This altered lipid profile, reflected by the metabolite ratio, contributes to the risk of pure hypercholesterolemia.10[4], 7[5], 9[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data