1-oleoyl-2-linoleoyl-gpe (18:1/18:2)* to 1-arachidonoyl-gpc (20:4n6)*

Numerator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-arachidonoyl-gpc (20:4n6)*
Metabolite Accession: GCST90199788
Name: 1-arachidonoyl-gpc (20:4n6)*
Hmdb Id: HMDB0010395
Super Pathway: NA
Sub Pathway: NA
Inchikey: LAXQYRRMGGEGOH

Associated Genomic Regions

Region: rs174533

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.954
Position:
61549025
SE (Ratio):
0.024
Effect Allele:
A
Z-score (Ratio):
39.909
Reference Allele:
G
-log10(P):
-800.266
MAF:
0.340
Beta (Num):
0.393
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.561
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine Biosynthesis5[1]

Denominator Metabolite Explanation:

Phosphatidylcholine Biosynthesis6[1]

Ratio Explanation:

The ratio reflects the relative activity of FADS1/FADS2, where lower activity leads to higher levels of precursors (like oleoyl and linoleoyl) and lower arachidonic acid.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in FADS1/FADS2 are associated with altered polyunsaturated fatty acid metabolism and circulating lipid levels, which are linked to valvular heart disease and cholelithiasis.7[1], 8[2], 9[3], 10[4], 11[5], 12[6], 13[7]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data