1-oleoyl-2-linoleoyl-gpe (18:1/18:2)* to 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)

Numerator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Metabolite Accession: GCST90200046
Name: 1-stearoyl-2-docosahexaenoyl-gpc (18:0/22:6)
Hmdb Id: HMDB0008057
Super Pathway: NA
Sub Pathway: NA
Inchikey: FAUYAENFVCNTAL

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.644
Position:
61569830
SE (Ratio):
0.024
Effect Allele:
T
Z-score (Ratio):
26.424
Reference Allele:
C
-log10(P):
-352.609
MAF:
0.341
Beta (Num):
0.396
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.247
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine (PE) biosynthesis, Glycerophospholipid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Phosphatidylcholine (PC) biosynthesis, Glycerophospholipid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio reflects the balance between oleic/linoleic acid and stearic/docosahexaenoic acid incorporation into different phospholipid classes, influenced by FADS desaturase activity.2[1], 8[2], 9[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variants in the FADS gene cluster are associated with altered FADS1/FADS2 expression and activity, which influences the balance of polyunsaturated fatty acids.1[1], 2[2], 10[3] This altered lipid profile is associated with variations in cholesterol levels, including pure hypercholesterolemia.11[4], 3[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data