1-oleoyl-2-linoleoyl-gpe (18:1/18:2)* to 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*

Numerator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Metabolite Accession: GCST90200054
Name: 1-palmitoyl-2-arachidonoyl-gpe (16:0/20:4)*
Hmdb Id: HMDB0005323
Super Pathway: NA
Sub Pathway: NA
Inchikey: DRIVXEVMDWCWLI

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.530
Position:
61557803
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
29.713
Reference Allele:
T
-log10(P):
-445.061
MAF:
0.348
Beta (Num):
0.390
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.140
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Phosphatidylethanolamine Biosynthesis

Denominator Metabolite Explanation:

Phosphatidylethanolamine Biosynthesis

Ratio Explanation:

This ratio reflects the activity of FADS1/FADS2, which convert oleic and linoleic acids to long-chain PUFAs like arachidonic acid, impacting membrane composition and signaling.1[1], 5[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, suggested by the eQTL, can alter the balance of fatty acids in phospholipids.5[1] This dysregulation of lipid metabolism is linked to an increased risk for pure hypercholesterolemia and cholelithiasis, potentially by affecting cholesterol transport and bile composition.7[2], 8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data