1-oleoyl-2-linoleoyl-gpe (18:1/18:2)* to 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*

Numerator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Metabolite Accession: GCST90200058
Name: 1-(1-enyl-stearoyl)-2-arachidonoyl-gpe (p-18:0/20:4)*
Hmdb Id: HMDB0005779
Super Pathway: NA
Sub Pathway: NA
Inchikey: URPXXNCTXCOATD

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.683
Position:
61588305
SE (Ratio):
0.025
Effect Allele:
G
Z-score (Ratio):
27.723
Reference Allele:
A
-log10(P):
-387.841
MAF:
0.345
Beta (Num):
0.395
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.288
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism, Kennedy pathway.5[1], 6[2]

Denominator Metabolite Explanation:

Plasmalogen synthesis, Glycerophospholipid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects FADS1/FADS2 activity; a higher ratio suggests reduced conversion of linoleic acid (18:2) derivatives to arachidonic acid (20:4) derivatives.1[1], 10[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1/FADS2 activity, indicated by an elevated ratio, alters polyunsaturated fatty acid balance, which is linked to dyslipidemia and inflammatory conditions like pure hypercholesterolemia and cholelithiasis.11[1], 12[2], 13[3], 14[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data