1-oleoyl-2-linoleoyl-gpe (18:1/18:2)* to linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*

Numerator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Metabolite Accession: GCST90200103
Name: linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1]*
Hmdb Id: HMDB0007257
Super Pathway: NA
Sub Pathway: NA
Inchikey: KRECEGQUDDMNAQ

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.711
Position:
61588305
SE (Ratio):
0.021
Effect Allele:
G
Z-score (Ratio):
33.969
Reference Allele:
A
-log10(P):
-580.682
MAF:
0.345
Beta (Num):
0.395
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.316
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Glycerolipid metabolism, PUFA metabolism

Ratio Explanation:

This ratio likely reflects FADS1/FADS2 activity, comparing a glycerophosphoethanolamine with precursor fatty acids to a diacylglycerol containing the downstream product arachidonic acid (20:4).1[1], 3[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter polyunsaturated fatty acid synthesis, modifying this lipid ratio. This dysregulation of lipid metabolism and inflammatory precursors is linked to an increased risk for pure hypercholesterolemia and cholelithiasis, as supported by colocalization and Mendelian Randomization analyses.4[1], 5[2]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data