1-oleoyl-2-linoleoyl-gpe (18:1/18:2)* to arachidonoylcarnitine (c20:4)

Numerator Metabolite

Metabolite Accession: GCST90200082
Name: 1-oleoyl-2-linoleoyl-gpe (18:1/18:2)*
Hmdb Id: HMDB0005349
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of arachidonoylcarnitine (c20:4)
Metabolite Accession: GCST90200150
Name: arachidonoylcarnitine (c20:4)
Hmdb Id: HMDB0006455
Super Pathway: NA
Sub Pathway: NA
Inchikey: RBFQHRALHSUPIA

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.661
Position:
61588305
SE (Ratio):
0.025
Effect Allele:
G
Z-score (Ratio):
26.989
Reference Allele:
A
-log10(P):
-367.716
MAF:
0.345
Beta (Num):
0.395
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.267
SE (Den):
0.015
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Glycerophospholipid metabolism

Denominator Metabolite Explanation:

Fatty acid transport, beta-oxidation

Ratio Explanation:

The ratio reflects the balance between glycerophospholipid synthesis (numerator) and the transport and breakdown of arachidonic acid (denominator), a process influenced by FADS enzymes.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter the production of arachidonic acid, a precursor for inflammatory signaling molecules.2[1], 5[2], 4[3] This dysregulation is linked to inflammatory conditions and benign colorectal neoplasms, likely through altered eicosanoid production.6[4], 7[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data