1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to lactosyl-n-palmitoyl-sphingosine (d18:1/16:0)

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Metabolite Accession: GCST90200083
Name: 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Hmdb Id: HMDB0011206
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEWXKAOBUSBJLD

Denominator Metabolite

Metabolite Accession: GCST90200055
Name: lactosyl-n-palmitoyl-sphingosine (d18:1/16:0)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1077989

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
14
Beta (Ratio):
-0.393
Position:
67975822
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-24.565
Reference Allele:
A
-log10(P):
-305.137
MAF:
0.476
Beta (Num):
-0.357
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.036
SE (Den):
0.015
No CNV overlap
rQTL cluster:
46
Reaction Distance:
NA
Closest Genes:
TMEM229B PLEKHH1 PIGH PLEK2 ARG2

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism, plasmalogen biosynthesis.4[1], 5[2]

Denominator Metabolite Explanation:

Glycosphingolipid biosynthesis, sphingolipid metabolism.6[1], 7[2]

Ratio Explanation:

The ratio contrasts plasmalogen and lactosylceramide levels, distinct membrane lipids whose balance is genetically associated with TMEM229B, a protein of unknown function.1[1], 8[2], 9[3], 10[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

No associated phenotype was provided; therefore, a causal link between TMEM229B, the lipid ratio, and a clinical outcome cannot be determined.

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data