1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to 1,2-dilinoleoyl-gpe (18:2/18:2)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Metabolite Accession: GCST90200083
Name: 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Hmdb Id: HMDB0011206
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEWXKAOBUSBJLD

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Associated Genomic Regions

Region: rs102275

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.395
Position:
61557803
SE (Ratio):
0.024
Effect Allele:
C
Z-score (Ratio):
-16.310
Reference Allele:
T
-log10(P):
-136.031
MAF:
0.346
Beta (Num):
-0.168
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.227
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Glycerophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Fatty acid biosynthesis.1[1], 5[2], 6[3]

Ratio Explanation:

The ratio reflects the balance between plasmalogen and polyunsaturated fatty acid-containing phospholipid synthesis, which is influenced by FADS1/FADS2 desaturase activity on fatty acid precursors.1[1], 2[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, impacting the balance of complex lipids. This dysregulation of fatty acid metabolism is linked to inflammation and metabolic disorders like asthma, inflammatory bowel disease, type 2 diabetes, and hypercholesterolemia.7[1], 8[2], 9[3], 10[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data