1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Metabolite Accession: GCST90200083
Name: 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Hmdb Id: HMDB0011206
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEWXKAOBUSBJLD

Denominator Metabolite

Structure of 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Metabolite Accession: GCST90200095
Name: 1-linoleoyl-2-linolenoyl-gpc (18:2/18:3)*
Hmdb Id: HMDB0008141
Super Pathway: NA
Sub Pathway: NA
Inchikey: HZGAVPNEGHQJID

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.402
Position:
61569830
SE (Ratio):
0.020
Effect Allele:
T
Z-score (Ratio):
-19.632
Reference Allele:
C
-log10(P):
-195.914
MAF:
0.339
Beta (Num):
-0.165
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.237
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Plasmalogen biosynthesis, Ether lipid metabolism.4[1]

Denominator Metabolite Explanation:

Phosphatidylcholine biosynthesis, PUFA metabolism.2[1], 5[2]

Ratio Explanation:

The ratio reflects FADS-mediated synthesis of polyunsaturated fatty acids (denominator) relative to plasmalogen synthesis (numerator).2[1], 4[2] Reduced FADS activity increases the ratio.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters desaturase activity, affecting the balance of pro- and anti-inflammatory PUFAs.6[1], 7[2], 8[3] This altered inflammatory state, reflected by the ratio, likely contributes to the risk of asthma, IBD, cholelithiasis, and metabolic disorders.9[4], 10[5], 11[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data