1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)* to dihomo-linolenoylcarnitine (c20:3n3 or 6)*

Numerator Metabolite

Structure of 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Metabolite Accession: GCST90200083
Name: 1-(1-enyl-palmitoyl)-2-palmitoyl-gpc (p-16:0/16:0)*
Hmdb Id: HMDB0011206
Super Pathway: NA
Sub Pathway: NA
Inchikey: PEWXKAOBUSBJLD

Denominator Metabolite

Metabolite Accession: GCST90200139
Name: dihomo-linolenoylcarnitine (c20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs61897793

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.399
Position:
61599347
SE (Ratio):
0.028
Effect Allele:
A
Z-score (Ratio):
-14.221
Reference Allele:
G
-log10(P):
-103.997
MAF:
0.180
Beta (Num):
-0.160
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
0.239
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 FADS3

LLM Analysis

Numerator Metabolite Explanation:

Ether lipid metabolism

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation

Ratio Explanation:

FADS1/2 activity influences PUFA availability, including dihomo-linolenic acid, impacting the balance between plasmalogen synthesis and fatty acid carnitine levels for energy metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter PUFA metabolism, which is reflected in the metabolite ratio and linked to inflammatory skin conditions like seborrhoeic dermatitis.4[1], 5[2] This altered lipid metabolism likely contributes to the chronic inflammation seen in associated phenotypes.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data