oleoylcholine to arachidonoylcholine

Numerator Metabolite

Structure of oleoylcholine
Metabolite Accession: GCST90200084
Name: oleoylcholine
Hmdb Id: HMDB0240596
Super Pathway: NA
Sub Pathway: NA
Inchikey: PVXGXBXEHLTWOE

Denominator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Associated Genomic Regions

Region: rs174547

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.205
Position:
61570783
SE (Ratio):
0.007
Effect Allele:
C
Z-score (Ratio):
27.503
Reference Allele:
T
-log10(P):
-381.737
MAF:
0.339
Beta (Num):
0.014
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.191
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Phospholipid metabolism

Denominator Metabolite Explanation:

Phospholipid metabolism

Ratio Explanation:

The ratio of oleoylcholine to arachidonoylcholine likely reflects the efficiency of converting oleic acid precursors to arachidonic acid, influenced by FADS1/FADS2 activity.4[1], 5[2], 6[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1/FADS2 alters the balance of pro-inflammatory (arachidonic acid-derived) and anti-inflammatory lipids, influencing susceptibility to inflammatory conditions and metabolic disorders like type 2 diabetes and cholelithiasis.3[1], 7[2], 8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data