glycosyl-n-palmitoyl-sphingosine (d18:1/16:0) to lactosyl-n-nervonoyl-sphingosine (d18:1/24:1)*

Numerator Metabolite

Metabolite Accession: GCST90200085
Name: glycosyl-n-palmitoyl-sphingosine (d18:1/16:0)
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of lactosyl-n-nervonoyl-sphingosine (d18:1/24:1)*
Metabolite Accession: GCST90200098
Name: lactosyl-n-nervonoyl-sphingosine (d18:1/24:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: MKOKWBRPIBQYJJ

Associated Genomic Regions

Region: rs35818294

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
4
Beta (Ratio):
0.350
Position:
47545141
SE (Ratio):
0.020
Effect Allele:
A
Z-score (Ratio):
17.419
Reference Allele:
C
-log10(P):
-154.796
MAF:
0.176
Beta (Num):
0.333
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.016
SE (Den):
0.020
No CNV overlap
rQTL cluster:
126
Reaction Distance:
NA
Closest Genes:
ATP10D CORIN COMMD8 GABRB1 NFXL1

LLM Analysis

Numerator Metabolite Explanation:

Sphingolipid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Sphingolipid metabolism.5[1], 3[2], 6[3]

Ratio Explanation:

The ratio reflects the balance between a precursor (glycosyl-n-palmitoyl-sphingosine) and a downstream product (lactosyl-n-nervonoyl-sphingosine) in the glycosphingolipid synthesis pathway, potentially influenced by ATP10D's role.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data