arachidonoylcholine to 1-linoleoyl-gpc (18:2)

Numerator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Denominator Metabolite

Structure of 1-linoleoyl-gpc (18:2)
Metabolite Accession: GCST90199742
Name: 1-linoleoyl-gpc (18:2)
Hmdb Id: HMDB0010386
Super Pathway: NA
Sub Pathway: NA
Inchikey: SPJFYYJXNPEZDW

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.320
Position:
61569830
SE (Ratio):
0.021
Effect Allele:
T
Z-score (Ratio):
-14.884
Reference Allele:
C
-log10(P):
-113.702
MAF:
0.337
Beta (Num):
-0.191
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Acetylcholine metabolism, Fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Lysophospholipid metabolism, Glycerophospholipid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

The ratio may reflect the balance between arachidonic acid synthesis by FADS enzymes for incorporation into choline esters versus linoleoyl-GPC availability.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS activity, influenced by genetic variants, can decrease arachidonic acid production, potentially altering inflammatory and lipid signaling pathways associated with cholelithiasis, type 2 diabetes, and cardiovascular diseases.10[1], 11[2], 12[3], 13[4]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data