arachidonoylcholine to 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*

Numerator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Denominator Metabolite

Metabolite Accession: GCST90200051
Name: 1-palmitoyl-2-dihomo-linolenoyl-gpc (16:0/20:3n3 or 6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs174546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.522
Position:
61569830
SE (Ratio):
0.022
Effect Allele:
T
Z-score (Ratio):
-23.466
Reference Allele:
C
-log10(P):
-278.701
MAF:
0.337
Beta (Num):
-0.191
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.331
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS2 FADS1 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Acetylcholine synthesis, Polyunsaturated fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, Polyunsaturated fatty acid metabolism.7[1], 8[2]

Ratio Explanation:

This ratio reflects the conversion of a dihomo-linolenic acid-containing phospholipid to an arachidonic acid-containing choline ester, a process influenced by FADS1 enzyme activity.9[1], 7[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1 gene variants alter enzyme activity, impacting the balance of pro-inflammatory lipids derived from arachidonic acid.10[1], 9[2], 11[3] This altered ratio is associated with inflammatory conditions like asthma, IBD, and cardiovascular diseases by affecting inflammatory and resolution pathways.4[4], 10[5]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data