arachidonoylcholine to 1,2-dilinoleoyl-gpe (18:2/18:2)*

Numerator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Denominator Metabolite

Structure of 1,2-dilinoleoyl-gpe (18:2/18:2)*
Metabolite Accession: GCST90200068
Name: 1,2-dilinoleoyl-gpe (18:2/18:2)*
Hmdb Id: HMDB0009093
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSCDRSKJTAQNNB

Associated Genomic Regions

Region: rs99780

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.420
Position:
61596633
SE (Ratio):
0.025
Effect Allele:
T
Z-score (Ratio):
-16.974
Reference Allele:
C
-log10(P):
-147.124
MAF:
0.343
Beta (Num):
-0.193
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.227
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis4[1]

Denominator Metabolite Explanation:

Phospholipid Biosynthesis5[1]

Ratio Explanation:

The ratio of arachidonoylcholine to 1,2-dilinoleoyl-GPE (18:2/18:2) may reflect the balance between fatty acid acylation for signaling and membrane composition, influenced by FADS activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

FADS1/FADS2 genetic variants influence fatty acid metabolism, which is associated with a risk of valvular heart disease, type 2 diabetes, and altered cholesterol levels.6[1], 7[2], 8[3], 9[4] This suggests a link between genetically determined fatty acid profiles and cardiometabolic phenotypes.

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data