arachidonoylcholine to dihomo-linolenoyl-choline

Numerator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Denominator Metabolite

Structure of dihomo-linolenoyl-choline
Metabolite Accession: GCST90200090
Name: dihomo-linolenoyl-choline
Hmdb Id: HMDB0240646
Super Pathway: NA
Sub Pathway: NA
Inchikey: CPIZQONKXRTJBX

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.274
Position:
61581764
SE (Ratio):
0.013
Effect Allele:
C
Z-score (Ratio):
-21.628
Reference Allele:
T
-log10(P):
-237.193
MAF:
0.306
Beta (Num):
-0.197
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.077
SE (Den):
0.018
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Ratio Explanation:

The ratio reflects the enzymatic efficiency of FADS1 in converting dihomo-linolenoyl-choline to arachidonoylcholine, a key step in fatty acid metabolism.1[1], 4[2], 5[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Reduced FADS1 activity, indicated by a lower ratio, is associated with altered lipid profiles and an increased risk of cholelithiasis and other metabolic disorders.6[1], 7[2], 8[3] This suggests a role for FADS1-mediated lipid metabolism in the development of these conditions.7[4]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data