arachidonoylcholine to 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*

Numerator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Denominator Metabolite

Structure of 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Metabolite Accession: GCST90200102
Name: 1-palmitoleoyl-2-linolenoyl-gpc (16:1/18:3)*
Hmdb Id: HMDB0008008
Super Pathway: NA
Sub Pathway: NA
Inchikey: MMUCLZZSNHBNFL

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
-0.462
Position:
61588305
SE (Ratio):
0.023
Effect Allele:
G
Z-score (Ratio):
-20.464
Reference Allele:
A
-log10(P):
-212.627
MAF:
0.341
Beta (Num):
-0.193
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.270
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Acetylcholine metabolism, fatty acid metabolism.3[1], 4[2]

Denominator Metabolite Explanation:

Glycerophospholipid metabolism, linoleic acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio reflects FADS enzyme activity, contrasting a downstream product containing arachidonic acid with a precursor-containing phosphatidylcholine, indicating polyunsaturated fatty acid metabolism efficiency.7[1], 8[2], 2[3]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

FADS1/FADS2 gene variants alter the balance of pro-inflammatory omega-6 (e.g., arachidonic acid) and anti-inflammatory omega-3 fatty acids.9[1], 10[2], 11[3] This dysregulation affects inflammatory (IBD, asthma), cardiovascular, and metabolic diseases (T2D, cholelithiasis) by modulating inflammatory mediators.12[4], 8[5], 13[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data