arachidonoylcholine to stearoylcholine*

Numerator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Denominator Metabolite

Structure of stearoylcholine*
Metabolite Accession: GCST90200113
Name: stearoylcholine*
Hmdb Id: HMDB0240648
Super Pathway: NA
Sub Pathway: NA
Inchikey: SGFBLYBOTWZDDE

Associated Genomic Regions

Region: rs174536

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.177
Position:
61551927
SE (Ratio):
0.011
Effect Allele:
C
Z-score (Ratio):
-15.465
Reference Allele:
A
-log10(P):
-122.546
MAF:
0.339
Beta (Num):
-0.190
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.014
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis

Denominator Metabolite Explanation:

Fatty acid biosynthesis

Ratio Explanation:

The ratio of arachidonoylcholine to stearoylcholine may reflect the activity of FADS1 in converting saturated fatty acids to polyunsaturated fatty acids available for choline esterification.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1 are linked to altered lipid profiles, including cholesterol levels.4[1] The ratio of arachidonoylcholine to stearoylcholine, influenced by FADS1 activity, is associated with disorders of lipoprotein metabolism and hypercholesterolemia, suggesting a causal link between FADS1 function, this specific lipid ratio, and dyslipidemia phenotypes.4[2]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data