arachidonoylcholine to linoleoylcholine*

Numerator Metabolite

Structure of arachidonoylcholine
Metabolite Accession: GCST90200086
Name: arachidonoylcholine
Hmdb Id: HMDB0240583
Super Pathway: NA
Sub Pathway: NA
Inchikey: NJSSWIYQGNCVTH

Denominator Metabolite

Structure of linoleoylcholine*
Metabolite Accession: GCST90200130
Name: linoleoylcholine*
Hmdb Id: HMDB0013213
Super Pathway: NA
Sub Pathway: NA
Inchikey: FDCFEKFQGUEBOI

Associated Genomic Regions

Region: rs174564

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
-0.263
Position:
61588305
SE (Ratio):
0.008
Effect Allele:
G
Z-score (Ratio):
-32.458
Reference Allele:
A
-log10(P):
-530.457
MAF:
0.341
Beta (Num):
-0.193
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.070
SE (Den):
0.016
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Glycerophospholipid metabolism.4[1]

Denominator Metabolite Explanation:

Fatty acid metabolism, Linoleic acid metabolism.5[1], 6[2]

Ratio Explanation:

The ratio of arachidonoylcholine to linoleoylcholine reflects the enzymatic efficiency of FADS1/FADS2 in converting linoleic acid precursors to arachidonic acid precursors.7[1], 8[2]

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 alter desaturase activity, affecting the arachidonoylcholine to linoleoylcholine ratio.7[1], 9[2] This dysregulation of polyunsaturated fatty acids is linked to an increased risk for hypercholesterolemia, cholelithiasis, and other inflammatory and metabolic disorders.7[3], 10[4], 11[5], 12[6]

Phenotype Driver:

Gene-centric:FADS1/FADS2

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data