methylsuccinoylcarnitine to ximenoylcarnitine (c26:1)*

Numerator Metabolite

Metabolite Accession: GCST90200089
Name: methylsuccinoylcarnitine
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Metabolite Accession: GCST90200149
Name: ximenoylcarnitine (c26:1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs1056425

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.474
Position:
53680090
SE (Ratio):
0.023
Effect Allele:
A
Z-score (Ratio):
20.368
Reference Allele:
G
-log10(P):
-210.662
MAF:
0.318
Beta (Num):
0.243
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.230
SE (Den):
0.016
No CNV overlap
rQTL cluster:
162
Reaction Distance:
NA
Closest Genes:
C1orf123 CPT2 MAGOH LRP8 SLC1A7

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid oxidation, BCAA catabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio may reflect CPT2 functional status; impaired CPT2 could decrease ximenoylcarnitine oxidation while byproducts like methylsuccinoylcarnitine accumulate from disturbed mitochondrial metabolism.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

none

Phenotype Driver:

none

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data