dihomo-linolenoyl-choline to glycerophosphorylcholine (gpc)

Numerator Metabolite

Structure of dihomo-linolenoyl-choline
Metabolite Accession: GCST90200090
Name: dihomo-linolenoyl-choline
Hmdb Id: HMDB0240646
Super Pathway: NA
Sub Pathway: NA
Inchikey: CPIZQONKXRTJBX

Denominator Metabolite

Structure of glycerophosphorylcholine (gpc)
Metabolite Accession: GCST90199629
Name: glycerophosphorylcholine (gpc)
Hmdb Id: HMDB0000086
Super Pathway: NA
Sub Pathway: NA
Inchikey: SUHOQUVVVLNYQR

Associated Genomic Regions

Region: rs174560

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
11
Beta (Ratio):
0.143
Position:
61581764
SE (Ratio):
0.019
Effect Allele:
C
Z-score (Ratio):
7.733
Reference Allele:
T
-log10(P):
-32.184
MAF:
0.309
Beta (Num):
0.077
Novel Locus:
Yes ✔️
SE (Num):
0.018
Beta (Den):
-0.066
SE (Den):
0.017
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
FADS1 FADS2 FEN1 TMEM258 MYRF

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Phosphatidylcholine catabolism; Choline metabolism.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio reflects the activity of FADS1 on its substrate DGLA (within dihomo-linolenoyl-choline) relative to the general turnover of choline phospholipids to GPC.4[1], 7[2], 1[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in FADS1 alters polyunsaturated fatty acid (PUFA) levels, which are precursors for inflammatory mediators.5[1], 9[2], 3[3] This dysregulation of inflammation and lipid profiles likely contributes to associated phenotypes like asthma, hypercholesterolemia, and cholelithiasis.10[4], 11[5], 3[6]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data